Records and firsts in spaceflight are broadly divided into crewed and uncrewed categories. Records involving animal spaceflight have also been noted in earlier experimental flights, typically to establish the feasibility of sending humans to outer space.

The notion of "firsts" in spaceflight follows a long tradition of firsts in aviation, but is also closely tied to the Space Race. During the 1950s and 1960s, the Soviet Union and the United States competed to be the first countries to accomplish various feats. In 1957, the Soviet Union launched Sputnik 1, the first artificial orbital satellite. In 1961, Soviet Vostok 1 cosmonaut Yuri Gagarin became the first person to enter space and orbit the Earth, and in 1969 American Apollo 11 astronaut Neil Armstrong became the first person to set foot on the Moon. No human has traveled beyond low Earth orbit since 1972, when the Apollo program ended.

During the 1970s, the Soviet Union directed its energies to human habitation of space stations of increasingly long durations. In the 1980s, the United States began launching its Space Shuttles, which carried larger crews and thus could increase the number of people in space at a given time. Following their first mission of détente on the 1975 Apollo-Soyuz Test Project, the Soviet Union and the United States again collaborated with each other on the Shuttle-Mir initiative, efforts which led to the International Space Station (ISS), which has been continuously inhabited by humans for over 20 years.

Other firsts in spaceflight involve demographics, private enterprise, and distance. Dozens of countries have sent at least one traveler to space. In 1963, Valentina Tereshkova became the first woman in space, aboard Vostok 6. In the early 21st century, private companies joined government agencies in crewed spaceflight: in 2004, the sub-orbital spaceplane SpaceShipOne became the first privately funded crewed craft to enter space; in 2020, SpaceX's Dragon 2 became the first privately developed crewed vehicle to reach orbit when it ferried a crew to the ISS. As of 2023, the uncrewed probe Voyager 1 is the most distant artificial object from the Earth, part of a small class of vehicles that are leaving the Solar System.